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In vitro scientific tests, 25C-NBOMe has actually been proven to exhibit cytotoxicity on neuronal cell traces SH-SY5Y, PC12, and SN471, plus the compound was a lot more powerful than methamphetamine at cutting down the visibility in the respective cells; the neurotoxicity from the compound includes activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.

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Notes: (1) TAAR1 exercise of ligands differs significantly involving species. Some agents which have been TAAR1 ligands in a few species are usually not in other species.

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